Macitentan Impurity 7 CAS 1433875-21-8
| CAS No. | 1433875-21-8 |
| Molecular Formula | C16H13Br2N5O2 |
| Molecular Weight | 467.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Macitentan Impurity 7 (CAS 1433875-21-8) is a certified pharmaceutical impurity reference standard with the molecular formula C16H13Br2N5O2 and a molecular weight of 467.11 g/mol.
The molecular framework of Macitentan Impurity 7 (C16H13Br2N5O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H13Br2N5O2 |
| Molecular Weight | 467.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Macitentan Standards
- Macitentan Impurity 34 (CAS CATO-C4X-117534)
- Macitentan Impurity 32 (CAS 1803092-45-6)
- Macitentan impurity 31 (CAS CATO-C4X-117531)
- Macitentan Impurity 33 (CAS 1642873-05-9)
- Macitentan Impurity 57 (CAS CATO-C4X-117557)
- Macitentan impurity 30 (CAS CATO-C4X-117530)
- Macitentan Impurity 25 (CAS 1393813-43-8)
- Macitentan Impurity 40 (CAS CATO-C4X-117540)
Recommended Standards
- Chlordisulfurylisocyanat (CAS 63549-29-1)
- 5-Chloro-3-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(2,4-dichlorobenzyl)pyridin-2(1H)-one (CAS 477858-13-2)
- 2-(3,5-Dibromo-4-((2-methylquinolin-6-yl)oxy)phenoxy)acetic acid (CAS 918946-55-1)
- tert-Butyl 4-(5-bromo-2-iodophenyl)piperazine-1-carboxylate (CAS 1820735-42-9)
- Bempedoic Acid Impurity N4 (CAS 119703-02-5)
- Clindamycin Impurity 72 (CAS CATO-C4X-134172)
- Butenafine Impurity 19 (CAS CATO-C4X-159619)
- N-(6-Amino-3-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)cyclopentanecarboxamide (CAS 524944-62-5)
- 4-Oxo-6-phenyl-4H-pyran-2-carboxylic acid (CAS 1083-01-8)
- 6-Bromo-1,2-benzisoxazole (CAS 1060802-88-1)
- tert-Butyl (2-bromo-5-chloropyridin-3-yl)carbamate (CAS 1870679-03-0)
- 2-((1-(2,4-Dichlorobenzyl)piperidin-4-yl)thio)quinoline (CAS 232618-17-6)
- 2-Methyl-3,5-dinitrobenzonitrile (CAS 948-31-2)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
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