Macitentan Impurity 34 CAS CATO-C4X-117534

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-117534
Molecular FormulaC16H12Br2N4O3
Molecular Weight468.10 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Macitentan Impurity 34 CAS CATO-C4X-117534 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 468.10 g/mol gives Macitentan Impurity 34 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Macitentan Impurity 34 (CAS CATO-C4X-117534) is a certified pharmaceutical impurity reference standard with the molecular formula C16H12Br2N4O3 and a molecular weight of 468.10 g/mol.

Based on its molecular formula C16H12Br2N4O3, Macitentan Impurity 34 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 468.10 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

CATO manufactures Macitentan Impurity 34 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC16H12Br2N4O3
Molecular Weight468.10 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity>95%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentBr-containing
Nitrogen Atoms4

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