Macitentan Impurity 33 CAS 1642873-05-9
| CAS No. | 1642873-05-9 |
| Molecular Formula | C16H11Br2ClN4O2 |
| Molecular Weight | 486.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C16H11Br2ClN4O2, Macitentan Impurity 33 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 486.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Macitentan Impurity 33 (CAS 1642873-05-9, C16H11Br2ClN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Macitentan Impurity 33 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H11Br2ClN4O2 |
| Molecular Weight | 486.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 4 |
Related Macitentan Standards
- Macitentan Impurity 57 (CAS CATO-C4X-117557)
- Macitentan Impurity 32 (CAS 1803092-45-6)
- Macitentan Impurity 34 (CAS CATO-C4X-117534)
- Macitentan Impurity 7 (CAS 1433875-21-8)
- Macitentan Impurity 21 (CAS CATO-C4X-117521)
- Macitentan Impurity 56 (CAS CATO-C4X-117556)
- Macitentan Impurity 16 (CAS 2211059-00-4)
- Macitentan impurity 31 (CAS CATO-C4X-117531)
Recommended Standards
- Canagliflozin Impurity 69 (CAS CATO-C4X-112369)
- 2-(Benzo[d][1,3]dioxol-5-yl)-N-isopentyl-3-(4-methoxyphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide (CAS 1022587-64-9)
- Canagliflozin Impurity 68 (CAS CATO-C4X-112368)
- 4,6-Bis((R)-4-benzyl-4,5-dihydrooxazol-2-yl)dibenzo[b,d]furan (CAS 1080596-47-9)
- Amphotericin B Impurity 24 (CAS CATO-C4X-184424)
- Benidipine Impurity 72 (CAS CATO-C4X-112072)
- Cefadroxil Impurity 27 (CAS 55102-13-1)
- ethyl 5-methyl-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate (CAS 929971-71-1)
- 6-(Methylsulfonyl)pyridine-3,4-diamine (CAS 1415387-41-5)
- Triaziflam (CAS 131475-57-5)
- 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine (CAS 450-60-2)
- Ethyl 3,5-dichloro-2-methylbenzoate (CAS 1552579-28-8)
- Roflumilast Impurity 47 (CAS CATO-C4X-108447)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com