Macitentan Impurity 25 CAS 1393813-43-8
| CAS No. | 1393813-43-8 |
| Molecular Formula | C15H19BrN4O4S |
| Molecular Weight | 431.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 431.30 g/mol gives Macitentan Impurity 25 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Macitentan Impurity 25 (CAS 1393813-43-8) is a certified pharmaceutical impurity reference standard with the molecular formula C15H19BrN4O4S and a molecular weight of 431.30 g/mol.
The molecular framework of Macitentan Impurity 25 (C15H19BrN4O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Macitentan Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H19BrN4O4S |
| Molecular Weight | 431.30 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 40 (CAS CATO-C4X-117540)
- Macitentan Impurity 12 (CAS 2300968-85-6)
- Macitentan impurity 30 (CAS CATO-C4X-117530)
- Macitentan Impurity 20 (CAS CATO-C4X-117520)
- Macitentan Impurity 6 (CAS CATO-C4X-11756)
- Macitentan impurity 31 (CAS CATO-C4X-117531)
- Macitentan Impurity 7 (CAS 1433875-21-8)
- Macitentan Impurity 34 (CAS CATO-C4X-117534)
Recommended Standards
- (Z)-N-(1-Bromo-1-(4-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide (CAS 1800044-69-2)
- (Z)-N-(1-Bromo-1-(2-fluorophenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide (CAS 1800044-68-1)
- 2-Ethoxyethyl 2,5,7-trinitro-9-oxo-9H-fluorene-4-carboxylate (CAS 115847-63-7)
- (2R,3S,5R)-5-(2-Acetamido-6-oxo-3H-purin-9(6H)-yl)-2-((phosphonooxy)methyl)tetrahydrofuran-3-yl acetate (CAS 51146-84-0)
- Rasagiline Impurity 4 (CAS 1276516-73-4)
- Pregabalin Impurity 143 (CAS CATO-C4X-1312143)
- Pinaverium Bromide Impurity 14 (CAS CATO-C4X-246714)
- (R)-4-(tert-butoxy)-4-oxo-2-(pyridin-2-ylmethyl)butanoic acid (CAS 2426657-56-7)
- 4-(3-(3-Bromophenoxy)propyl)morpholine (CAS 1002056-86-1)
- 4-(2,3-Dihydrobenzofuran-5-yl)butan-2-ol (CAS 1468710-55-5)
- 1,5-Dibromonaphthalene (CAS 7351-74-8)
- Daptomycin impurity 52 (CAS CATO-C4X-137852)
- 3-[1-(3-Methoxybenzoyl)piperidin-4-yl]-4-[(4-methylphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775548-62-3)
- Semaglutide Impurity 6 (CAS 62-57-7)
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