Carbamazepine Impurity 12 CAS 143667-53-2
| CAS No. | 143667-53-2 |
| Molecular Formula | C15H9BrClNO |
| Molecular Weight | 334.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Carbamazepine Impurity 12 (CAS 143667-53-2) is a certified pharmaceutical impurity reference standard with the molecular formula C15H9BrClNO and a molecular weight of 334.60 g/mol.
Based on its molecular formula C15H9BrClNO, Carbamazepine Impurity 12 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 334.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H9BrClNO |
| Molecular Weight | 334.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Carbamazepine Standards
- Carbamazepine Impurity 11 (CAS 33948-20-8)
- Carbamazepine Impurity 17 (CAS CATO-C4X-118117)
- Carbamazepine Impurity 22 (CAS CATO-C4X-118122)
- Carbamazepine EP Impurity G (CAS 59690-97-0)
- Carbamazepine Impurity 19 (CAS CATO-C4X-118119)
- Carbamazepine Impurity 15 (CAS CATO-C4X-118115)
- Carbamazepine Impurity 23 (CAS CATO-C4X-118123)
- Carbamazepine Impurity 32 (CAS 40421-05-4)
Recommended Standards
- N-(4-bromophenyl)-7-chloroquinazolin-4-amine (CAS 477856-29-4)
- Bromfenac Impurity 10 (CAS 91714-51-1)
- 5-Bromo-2-(4-chlorophenyl)-1H-indole-3-carbaldehyde (CAS 587828-26-0)
- Bromfenac Impurity 11 (CAS CATO-C4X-200211)
- Bempedoic Acid Impurity 35 (CAS CATO-C4X-218935)
- Isoprenaline Impurity 27 (CAS CATO-C4X-277527)
- Rasagiline Impurity 7 (CAS 6351-10-6)
- tert-Butyl 2-(2-hydroxyethylsulfonyl)-ethylcarbamate (CAS 142604-13-5)
- 3-(2-Methylnaphtho[1,2-d]thiazol-1-ium-1-yl)propane-1-sulfonate (CAS 3176-77-0)
- 4-(Dimethylamino)pyridinium chlorochromate (CAS 81121-61-1)
- Defensin HNP-1 (Human) (CAS 99287-08-8)
- 2-(Methylamino)-1-(3-nitrophenyl)ethan-1-ol (CAS 23833-11-6)
- Butyl Carbamate (CAS 592-35-8)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
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