2-(2-(2-Chloro-5-(trifluoromethyl)phenoxy)ethyl)-1,3-dioxolane CAS 1443303-77-2
| CAS No. | 1443303-77-2 |
| Molecular Formula | C12H12ClF3O3 |
| Molecular Weight | 296.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2-(2-Chloro-5-(trifluoromethyl)phenoxy)ethyl)-1,3-dioxolane (CAS 1443303-77-2), molecular formula C12H12ClF3O3 and molecular weight 296.67 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(2-(2-Chloro-5-(trifluoromethyl)phenoxy)ethyl)-1,3-dioxolane (C12H12ClF3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(2-(2-Chloro-5-(trifluoromethyl)phenoxy)ethyl)-1,3-dioxolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12ClF3O3 |
| Molecular Weight | 296.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- Ethyl 2-(4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1h-pyrazol-1-yl)acetate (CAS 1002033-65-9)
- Methyl 3-(4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propanoate (CAS 1005583-79-8)
- Methyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-2-methylpropanoate (CAS 1354448-69-3)
- (2-Chloro-6-trifluoromethyl-pyridin-4-yl)-carbamic acid tert-butyl ester (CAS 1373223-18-7)
- 2-(2-(2-Chloro-4-(trifluoromethyl)phenoxy)ethyl)-1,3-dioxolane (CAS 1443303-07-8)
- Ethyl 3-(2-chloro-5-(trifluoromethyl)phenoxy)propanoate (CAS 1443303-84-1)
- Ethyl 3-(2-chloro-4-(trifluoromethyl)phenoxy)propanoate (CAS 1443345-65-0)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indole (CAS 151387-66-5)
Recommended Standards
- tert-Butyl (6-chloro-5-(trifluoromethyl)pyridin-3-yl)carbamate (CAS 1057383-91-1)
- (S)-(-)-NBD-Pro-COCl [=(S)-(-)-4-Nitro-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] (CAS 159717-68-7)
- 2-(4-Chlorophenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 1011709-58-2)
- (R)-(+)-NBD-Pro-COCl [=(R)-(+)-4-Nitro-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] (CAS 159717-69-8)
- (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate (CAS 137255-86-8)
- 3-Bromo-4-methyl-1,5-naphthyridin-2-amine (CAS 1820683-25-7)
- 6-(Bromomethyl)-2-chloroquinoline (CAS 123637-77-4)
- 3,3'-Bi-1,2-benzisothiazole (CAS 1195571-46-0)
- 4-Chloro-6-cyclohexyl-2-methylpyrimidine (CAS 1412957-40-4)
- 2508-29-4 3,4-dibromo-5-(4-butoxyphenyl)furan-2(5h)-one AR-1E9053 (CAS 2508-29-4)
- 5-(2-Chloroallyl)-2-methoxy-1,3-dimethylbenzene (CAS 951893-05-3)
- 2-(6-Bromo-5-methylpyridin-3-yl)-6-methylpyrazine (CAS 1956325-44-2)
- 8-Chloro-2-(3,4-dimethoxyphenyl)quinoline-4-carboxylic acid (CAS 862782-46-5)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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