Beclometasone Dipropionate Monohydrate EP Impurity O CAS 14527-61-8
| CAS No. | 14527-61-8 |
| Molecular Formula | C28H36Cl2O6 |
| Molecular Weight | 539.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Beclometasone Dipropionate Monohydrate EP Impurity O (CAS 14527-61-8, C28H36Cl2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Beclometasone Dipropionate Monohydrate EP Impurity O (C28H36Cl2O6) contains a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Beclometasone Dipropionate Monohydrate EP Impurity O meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H36Cl2O6 |
| Molecular Weight | 539.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
Related Beclometasone Standards
- Beclometasone Dipropionate Monohydrate EP Impurity C (CAS CATO-C4X-14743)
- Beclometasone Dipropionate Monohydrate EP Impurity E (CAS 887130-68-9)
- Beclometasone Dipropionate Monohydrate EP Impurity L (CAS 114371-33-4)
- Beclometasone Dipropionate EP Impurity M (CAS 3100114-15-3)
- Beclometasone Impurity 52 (CAS CATO-C4X-147452)
- Beclometasone Dipropionate Monohydrate EP Impurity D (CAS 52092-14-5)
- Beclometasone dipropionate EP Impurity B (CAS 5534-08-7)
- Beclometasone dipropionate EP Impurity S (CAS 1709825-83-1)
Recommended Standards
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- N-Nitroso Vilazodone Impurity 9 (CAS CATO-C4X-13559)
- 4-Hydroxypentanoic acid (CAS 13532-37-1)
- 6-Iodo-2-methyl-4H-benzo[d][1,3]oxazin-4-one (CAS 40889-40-5)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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