Beclometasone dipropionate EP Impurity B CAS 5534-08-7
| CAS No. | 5534-08-7 |
| Molecular Formula | C27H35ClO7 |
| Molecular Weight | 507.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Beclometasone dipropionate EP Impurity B is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Beclometasone dipropionate EP Impurity B (CAS 5534-08-7, C27H35ClO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Beclometasone dipropionate EP Impurity B (C27H35ClO7) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 507.02 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Beclometasone dipropionate EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H35ClO7 |
| Molecular Weight | 507.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Beclometasone Standards
- Beclometasone Impurity 51 (CAS CATO-C4X-147451)
- Beclometasone Dipropionate EP Impurity M (CAS 3100114-15-3)
- Beclometasone Impurity 52 (CAS CATO-C4X-147452)
- Beclometasone Dipropionate Monohydrate EP Impurity L (CAS 114371-33-4)
- Beclometasone Impurity 43 (CAS CATO-C4X-147443)
- Beclometasone Dipropionate Monohydrate EP Impurity C (CAS CATO-C4X-14743)
- Beclometasone Dipropionate Monohydrate EP Impurity O (CAS 14527-61-8)
- Beclometasone Dipropionate Monohydrate EP Impurity Q (CAS CATO-C4X-147417)
Recommended Standards
- N-((S)-1-amino-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-3-chloro-4-isopropoxybenzamide (CAS 1240137-87-4)
- 3-[(2-Chloro-6-{[1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptan-2-yl]oxy}phenyl)methyl]-1-(4-methylbenzenesulfonyl)urea (CAS 1005096-46-7)
- AV-412 (CAS 451492-95-8)
- 1,2,3,4,5-Pentabromo-6-chlorobenzene (CAS 13075-05-3)
- Posaconazole Impurity 21(R,R,S,R) (CAS 171228-50-5)
- Ipratropium Impurity 38 (CAS 40195-49-1)
- Albendazole EP Impurity L (CAS 108579-67-5)
- JWH-302 (CAS 864445-45-4)
- Chloroform-d (CAS 865-49-6)
- 3-Amino-5,5-dimethylhexanoic acid (CAS 727971-57-5)
- Furan-2-carboxylic acid {2-[(pyridin-2-ylmethyl)-amino]-ethyl}-amide hydrobromide (CAS 1052539-91-9)
- (E)-1-[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-3-(4-methoxyphenyl)-2-propen-1-one (CAS 1164520-79-9)
- 3,5-Difluoro-4-methoxybenzoyl chloride (CAS 501701-43-5)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
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