Amiodarone Hydrochloride EP Impurity F CAS 147030-50-0
| CAS No. | 147030-50-0 |
| Molecular Formula | C19H17IO3 |
| Molecular Weight | 420.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Amiodarone Hydrochloride EP Impurity F (CAS 147030-50-0, C19H17IO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Amiodarone Hydrochloride EP Impurity F (C19H17IO3) contains a steroid core, a hydroxyl group, an ether linkage, iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 420.24 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Amiodarone Hydrochloride EP Impurity F under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H17IO3 |
| Molecular Weight | 420.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | I-containing |
Related Amiodarone Standards
- Amiodarone Impurity 34 (CAS 159980-56-0)
- Amiodarone Impurity 41 (CAS CATO-C4X-142541)
- Amiodarone EP Impurity A (CAS 23551-25-9)
- Amiodarone Impurity 23 (CAS CATO-C4X-142523)
- Amiodarone Impurity 49 (CAS CATO-C4X-142549)
- Amiodarone Impurity 50 (CAS CATO-C4X-142550)
- Amiodarone Impurity 19 (CAS CATO-C4X-142519)
- Amiodarone EP Impurity C (CAS 85642-08-6)
Recommended Standards
- 2-Amino-4-(3-iodophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (CAS 337496-56-7)
- Nintedanib Impurity 143 (CAS CATO-C4X-1814143)
- Propanedioic acid, 2-(6-iodo-3-pyridazinyl)-, 1,3-bis(1,1-dimethylethyl) ester (CAS 1853166-10-5)
- Nintedanib Impurity 144 (CAS CATO-C4X-1814144)
- Dopamine Impurity 19 (CAS 16240-59-8（free base）)
- Nystatin Impurity 6 Dilithium Salt (CAS CATO-C4X-17166)
- Meclofenoxate Impurity 4 (CAS CATO-C4X-24694)
- 5-(4-Amino-phenoxy)-pentanoic acid ethyl ester (CAS 163259-94-7)
- S-Tetrahydrobiopterin Dihydrochloride (CAS 69056-39-9)
- (S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,4-dimethoxybenzyl)propanoic acid (CAS 1260601-67-9)
- 2-(5-Chloropyrimidin-4-yl)acetonitrile (CAS 1261737-95-4)
- (2-(1,3,5-Trimethyl-1H-pyrazol-4-yl)quinolin-4-yl)methanol (CAS 1354706-40-3)
- 1-(6-(tert-Butylamino)-4-methylpyridin-3-yl)ethanol (CAS 1355216-44-2)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com