Atorvastatin Impurity N1 CAS 148127-12-2
| CAS No. | 148127-12-2 |
| Molecular Formula | 2*C33H32FN2O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Atorvastatin Impurity N1 (CAS 148127-12-2, C33H32FN2O6Ca) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Atorvastatin Impurity N1 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 611.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Atorvastatin Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C33H32FN2O6 Ca |
| Molecular Weight | 611.70 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 22 (CAS 1035205-25-4)
- Atorvastatin Calcium Propylene Glycol Solvate (CAS 1040350-07-9)
- Atorvastatin Lactone Diepoxide (CAS 1046118-40-4)
- Atorvastatin Lactam calcium Salt Impurity (CAS 1046118-41-5)
- Atorvastatin Impurity 86 (CAS 1046118-44-8)
- Atorvastatin Impurity 141 Calcium Salt (CAS 1046378-58-8)
- Atorvastatin Impurity 76 (CAS 1099474-28-8)
- Atorvastatin EP Impurity F(Calcium Salt) (CAS 1105067-87-5)
Recommended Standards
- Maribavir Impurity 29 (CAS CATO-C4X-300729)
- Pitavastatin Impurity 99 (CAS 176593-07-0)
- Lifitegrast Impurity 159 (CAS CATO-C4X-2409159)
- 5-(((6-Chloropyridin-3-yl)methyl)thio)-4h-1,2,4-triazol-3-amine (CAS 1094626-28-4)
- N-cyclohexyl-2-(3-hydroxypyrrolidin-1-yl)acetamide (CAS 1339198-56-9)
- Methyl 3-(tert-butyl)-5-chlorobenzoate (CAS 1000341-35-4)
- Prucalopride Impurity 53 (CAS CATO-C4X-103853)
- 1-(2-Ethyl-1-(1-methoxypropan-2-yl)-1H-imidazol-5-yl)ethanone (CAS 600699-63-6)
- 2-amino-2,3-dihydro-1H-indene-2-carboxamide hydrochloride (CAS 1311318-47-4)
- Angiotensin II Antipeptide (CAS 121379-63-3)
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