Apixaban impurity 158 CAS 148476-97-5
| CAS No. | 148476-97-5 |
| Molecular Formula | C20H22Cl2O4 |
| Molecular Weight | 397.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Apixaban impurity 158 (CAS 148476-97-5, C20H22Cl2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Apixaban impurity 158 (C20H22Cl2O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures Apixaban impurity 158 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H22Cl2O4 |
| Molecular Weight | 397.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
Related Apixaban Standards
- Apixaban Impurity 63 (CAS 1466571-07-2)
- Apixaban Impurity 140 (CAS CATO-C4X-1088140)
- Apixaban Impurity 26 (CAS 1643330-62-4)
- Apixaban Impurity 103 (CAS CATO-C4X-1088103)
- Apixaban Impurity 145 (CAS CATO-C4X-1088145)
- Apixaban Impurity 83 (CAS CATO-C4X-108883)
- Apixaban Impurity 180 (CAS CATO-C4X-1088180)
- Apixaban Impurity 161 (CAS CATO-C4X-1088161)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com