Alogliptin Impurity 64 CAS 1485536-93-3
| CAS No. | 1485536-93-3 |
| Molecular Formula | C8H4Br2FN |
| Molecular Weight | 292.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Alogliptin Impurity 64 (C8H4Br2FN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Alogliptin Impurity 64 (CAS 1485536-93-3, C8H4Br2FN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Alogliptin Impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4Br2FN |
| Molecular Weight | 292.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Alogliptin Standards
- Alogliptin Impurity 100 (CAS CATO-C4X-1099100)
- Alogliptin Impurity 56 (CAS 454713-13-4)
- Alogliptin Impurity 67 (CAS 865759-24-6)
- Alogliptin Impurity 46 (CAS 1430222-06-2)
- Alogliptin Impurity 50 (CAS 1883825-48-6)
- Alogliptin Impurity 44-d3 (CAS 1794937-18-0)
- Alogliptin Impurity 17 (CAS 865758-96-9)
- Alogliptin Impurity 27 (CAS CATO-C4X-109927)
Recommended Standards
- 4-(DIBROMOMETHYL)-2-FLUOROBENZONITRILE (CAS 440105-58-8)
- 3-Bromo-6,7-dichloroquinolin-4(1H)-one (CAS 1204810-30-9)
- 2,4-Dibromo-6-fluorophenylacetonitrile (CAS 497181-24-5)
- 3-Bromo-5,7-dichloroquinolin-4(1H)-one (CAS 1204810-37-6)
- Hydantoin Impurity N9 (CAS 42579-28-2)
- Lifitegrast Impurity 98 (CAS CATO-C4X-240998)
- Norfloxacin Impurity 44 (CAS 140700-98-7)
- Ethyl N-[(2Z)-2-{[(3-chloro-4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)amino]methylidene}-3-oxobutanoyl]carbamate (CAS 338770-16-4)
- 2-Methylthian-4-amine (CAS 60743-26-2)
- tert-Butyl (1S,5S)-3,6-diazabicyclo[3.2.0]heptane-3-carboxylate (CAS 956276-42-9)
- N-allyl-2-amino-4-methylthiazole-5-sulfonamide (CAS 1344305-94-7)
- 2-(3-Thioxo-3H-1,2,4-triazol-5-yl)acetic acid (CAS 65926-79-6)
- 1-(4-Bromophenyl)-3-(2-methoxyethyl)urea (CAS 195452-20-1)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
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