Bromhexine Impurity N1 CAS 14860-48-1
| CAS No. | 14860-48-1 |
| Molecular Formula | C13H18Br2N2 |
| Molecular Weight | 362.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Bromhexine Impurity N1 (CAS 14860-48-1), a pharmacopoeial impurity reference standard (molecular formula C13H18Br2N2, MW 362.10 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution, Bromhexine Impurity N1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 362.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18Br2N2 |
| Molecular Weight | 362.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bromhexine Standards
- Bromhexine Impurity N3 (CAS 114390-41-9)
- Bromhexine Impurity 50 (CAS 18683-92-6)
- Bromhexine (CAS 3572-43-8)
- Bromhexine impurity 59 (CAS 100669-81-6)
- Bromhexine Impurity 17 (CAS 114390-40-8)
- Bromhexine Impurity 10 (CAS 2512203-87-9)
- Bromhexine Impurity 11 (CAS 21237-84-3)
- Bromhexine Impurity 20 (CAS CATO-C4X-106020)
Recommended Standards
- 4-(4-Bromophenoxy)-1-nitro-2-(trifluoromethyl)benzene (CAS 1156314-30-5)
- 1-(4-Bromophenoxy)-2-nitro-4-(trifluoromethyl)benzene (CAS 1744-23-6)
- 1-(3-Bromophenoxy)-2-nitro-4-(trifluoromethyl)benzene (CAS 1096951-88-0)
- 1-(2-Bromophenoxy)-2-nitro-4-(trifluoromethyl)benzene (CAS 2069-14-9)
- Safinamide Impurity 4 (CAS CATO-C4X-15904)
- Bortezomib Impurity N32 (CAS 84110-34-9)
- Levodopa Impurity 13 (CAS 1176784-51-2)
- Ethyl 2-phenyl-4-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 149771-11-9)
- 4-(2-chloro-4-methylphenoxy)butanoic acid (CAS 40629-77-4)
- Chlorpromazine EP Impurity E (CAS 92-39-7)
- 2-Chloro-n-methylpyrimidine-5-carboxamide (CAS 1360443-21-5)
- 4-(5-Amino-1-methyl-1H-benzo[d]imidazol-2-yl)butan-2-ol dihydrochloride (CAS 1158490-09-5)
- 1-(2-(Iodomethyl)pyrrolidin-1-yl)ethanone (CAS 1353973-07-5)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com