Metoprolol EP Impurity O HCl CAS 1486464-40-7
| CAS No. | 1486464-40-7 |
| Molecular Formula | C27H41NO6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Metoprolol EP Impurity O HCl is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Metoprolol EP Impurity O HCl (CAS 1486464-40-7), a pharmacopoeial impurity reference standard (molecular formula C27H41NO6HCl, MW 512.08 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C27H41NO6HCl, Metoprolol EP Impurity O HCl contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 512.08 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H41NO6 HCl |
| Molecular Weight | 512.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Metoprolol Standards
- Metoprolol EP Impurity A (CAS 109632-08-8)
- Metoprolol Impurity 23 (CAS 109632-11-3)
- Metoprolol Impurity 9 (CAS 1155083-53-6)
- Metoprolol Acid-d5 Ethyl Ester (CAS 1189704-28-6)
- Metoprolol Fumarate (CAS 119637-66-0)
- Metoprolol Acid-d5 (CAS 1215404-47-9)
- Metoprolol-D7 Hydrochloride (CAS 1219798-61-4)
- Metoprolol Impurity 22 (CAS 123195-72-2)
Recommended Standards
- Estradiol Impurity 57 (CAS CATO-C4X-163657)
- Lubiprostone Impurity 15 (CAS CATO-C4X-113615)
- Clarithromycin EP Impurity O (CAS 127252-80-6)
- Cyclopentyl hydroxycarbamate (CAS 2095641-48-6)
- 2-(Pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid (CAS 1368391-90-5)
- 3-Chloro-6-fluoroquinoline (CAS 1783716-90-4)
- 4-chlorothieno[3,2-c]pyridine-2-carbaldehyde (CAS 1296224-97-9)
- 2-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethan-1-amine (CAS 1248157-58-5)
- Ethyl 2-cyano-2-(4-fluorophenyl)acetate (CAS 15032-42-5)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
Why CATO?
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