Macitentan Impurity 14 CAS 2211059-05-9
| CAS No. | 2211059-05-9 |
| Molecular Formula | C12H12BrN3O2 |
| Molecular Weight | 310.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Macitentan Impurity 14 (C12H12BrN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Macitentan Impurity 14 (CAS 2211059-05-9) is a certified pharmaceutical impurity reference standard with the molecular formula C12H12BrN3O2 and a molecular weight of 310.15 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Macitentan Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12BrN3O2 |
| Molecular Weight | 310.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Macitentan Standards
- Macitentan Impurity 42 (CAS CATO-C4X-117542)
- Macitentan Impurity 38 (CAS 2211054-17-8)
- Macitentan Impurity 15 (CAS 1642873-04-8)
- Macitentan Impurity 10 (CAS 149506-35-4)
- Macitentan Impurity 36 (CAS CATO-C4X-117536)
- Macitentan Impurity 46 (CAS CATO-C4X-117546)
- Macitentan Impurity 48 (CAS CATO-C4X-117548)
- Macitentan Impurity 41 (CAS CATO-C4X-117541)
Recommended Standards
- Ethyl 5-amino-1-(3-bromophenyl)-1H-pyrazole-4-carboxylate (CAS 494747-19-2)
- Crisaborole Impurity 51 (CAS 2925547-76-6)
- Ethyl 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate (CAS 361990-21-8)
- n-(5-Bromo-2-methoxybenzyl)-2-fluoroaniline (CAS 1094280-73-5)
- Rifamycin Impurity 18 (CAS CATO-C4X-200418)
- Hexamidine EP Impurity D (CAS 2514722-87-1)
- Dronedarone Impurity 49 (CAS CATO-C4X-109249)
- 2-(Pyrimidin-2-yl)propan-1-ol (CAS 191725-66-3)
- 2-[[3-(2-chloroethyl)-2-oxidanylidene-1,3,2$l^{5}-oxazaphosphinan-2-yl]amino]ethyl ethanesulfonate 4430-45-9 A826535 ethanesulfonic acid 2-[[3-(2-chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphorinan-2-yl]amino]ethyl ester (CAS 4430-45-9)
- 6-Chloro-5-nitro-2,3-dihydro-1H-indole (CAS 172078-32-9)
- 1-Methyl-3-(3-nitrophenyl)-1H-pyrazole (CAS 886851-64-5)
- 6-cyclopropyl-1H-indole-3-sulfonic acid (CAS 2360991-75-7)
- Betamethasone impurity 70 (CAS 1201919-11-0)
- Semaglutide impurity 103 (CAS 1446013-07-5)
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