Cinacalcet Impurity 8 CAS 1517-72-2
| CAS No. | 1517-72-2 |
| Molecular Formula | C12H12O |
| Molecular Weight | 172.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Cinacalcet Impurity 8 is closely related to a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Cinacalcet Impurity 8 (CAS 1517-72-2, C12H12O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Cinacalcet Impurity 8 (C12H12O) contains a hydroxyl group, an ether linkage, an aromatic ring system. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12O |
| Molecular Weight | 172.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Cinacalcet Standards
- Cinacalcet Impurity 4 (CAS 7228-47-9)
- Cinacalcet Impurity 26 (CAS 42882-31-5)
- Cinacalcet Impurity 42 (CAS 3906-16-9)
- Cinacalcet Impurity 23 (CAS 3886-70-2)
- Cinacalcet Impurity 26 (CAS 1201-74-7)
- Cinacalcet Impurity 48 (CAS 10420-89-0)
- Cinacalcet Impurity 29 (CAS 1020414-30-5)
- Cinacalcet Impurity 28 (CAS 802918-45-2)
Recommended Standards
- 3-Ethyl-3-Methylpentanediamide (CAS 90152-42-4)
- Tofacitinib Impurity 127 (CAS 1204176-45-3)
- Ethyl 3-Hydroxycyclohexanecarboxylate 94160-25-5 MFCD00205586 SY110653 (CAS 94160-25-5)
- Tofacitinib Impurity 246 (CAS CATO-C4X-1079246)
- Altrenogest impurity 12 (CAS 23760-34-1)
- Ceftizoxime impurity 95 (CAS CATO-C4X-179395)
- Thiamine Impurity N1 (CAS 7403-34-1)
- Ethyl 4-bromo-5,7-dimethylquinoline-3-carboxylate (CAS 1242260-06-5)
- 3-(Trimethoxysilyl)propyl 3-oxobutanoate (CAS 121505-13-3)
- (4-((2-Fluoroethyl)thio)phenyl)boronic acid (CAS 958451-96-2)
- 2,4-Dimethyl-6-nitro-benzoic acid (CAS 1379173-92-8)
- 2-(3-(Aminomethyl)tetrahydrofuran-3-yl)acetic acid (CAS 1512659-68-5)
- 5-(Aminomethyl)-2-(trifluoromethyl)benzoic acid (CAS 1381846-25-8)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
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