Tofacitinib Impurity 246 CAS CATO-C4X-1079246
| CAS No. | CATO-C4X-1079246 |
| Molecular Formula | C8H16N2O2 |
| Molecular Weight | 172.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tofacitinib Impurity 246 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Tofacitinib Impurity 246 (CAS CATO-C4X-1079246), a pharmacopoeial impurity reference standard (molecular formula C8H16N2O2, MW 172.22 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C8H16N2O2, Tofacitinib Impurity 246 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic functional-group stretching vibrations in infrared spectroscopy. The molecular weight of 172.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H16N2O2 |
| Molecular Weight | 172.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 2.0 |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 127 (CAS 1204176-45-3)
- Tofacitinib Impurity 140 (CAS CATO-C4X-1079140)
- Tofacitinib Impurity 220 (CAS 1279816-72-6)
- Tofacitinib Impurity 206 (CAS CATO-C4X-1079206)
- Tofacitinib Impurity 52 (CAS 694495-63-1)
- Tofacitinib Impurity 149 (CAS 861612-04-6)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 82 (CAS 1229041-97-7)
Recommended Standards
- Zopiclone Impurity 16 (CAS 59325-11-0)
- Cinacalcet Impurity 8 (CAS 1517-72-2)
- 1-(Methoxymethyl)naphthalene (CAS 5903-23-1)
- 3-Ethyl-3-Methylpentanediamide (CAS 90152-42-4)
- Tacrolimus Impurity 27 (CAS 104987-25-9)
- Sucralose EP Impurity I (CAS 848642-13-7)
- Obeticholic Acid Impurity 48 (CAS CATO-C4X-115348)
- Methyl formylcarbamate (CAS 30690-19-8)
- 6,6-Difluoro-4-azaspiro[2.4]heptane (CAS 2315377-39-8)
- 2,6-Di-tert-butyl-4-(6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenol (CAS 129244-66-2)
- 5-Nitro-2-(phenylthio)pyridine (CAS 4262-10-6)
- Benzyl 4-bromo-2-methylphenylcarbamate (CAS 1245563-07-8)
- 1-((6-Chloroimidazo[1,2-a]pyridin-2-yl)methyl)-1H-imidazole-4-carboxylic acid (CAS 1707394-71-5)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com