Tafamidis impurity 11 CAS 1521571-08-3
| CAS No. | 1521571-08-3 |
| Molecular Formula | C14H8ClNO3 |
| Molecular Weight | 273.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Tafamidis impurity 11 (CAS 1521571-08-3, C14H8ClNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tafamidis impurity 11 (C14H8ClNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8ClNO3 |
| Molecular Weight | 273.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tafamidis Standards
- Tafamidis Impurity N1 (CAS 1018498-30-0)
- Tafamidis Impurity 14 (CAS CATO-C4X-287714)
- Tafamidis Impurity 15 (CAS CATO-C4X-287715)
- Tafamidis (CAS 594839-88-0)
- Tafamidis impurity 10 (CAS CATO-C4X-287710)
- Tafamidis Impurity 6 (CAS 1507158-86-2)
- Tafamidis Impurity 9 (CAS 1395964-06-3)
- Tafamidis Impurity 1 (CAS 1184581-58-5)
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