4-Chloro-5-fluoro-2-(trifluoromethyl)quinazoline CAS 1523184-16-8
| CAS No. | 1523184-16-8 |
| Molecular Formula | C9H3ClF4N2 |
| Molecular Weight | 250.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-Chloro-5-fluoro-2-(trifluoromethyl)quinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-Chloro-5-fluoro-2-(trifluoromethyl)quinazoline (CAS 1523184-16-8) is a high-purity analytical reference standard with the molecular formula C9H3ClF4N2 and a molecular weight of 250.58 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, 4-Chloro-5-fluoro-2-(trifluoromethyl)quinazoline is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 250.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H3ClF4N2 |
| Molecular Weight | 250.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-7-fluoro-2-(trifluoromethyl)quinazoline (CAS 1270920-38-1)
- 4-Chloro-8-fluoro-2-(trifluoromethyl)quinazoline (CAS 959238-18-7)
- 3-(3-Chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanenitrile (CAS 1053658-44-8)
- 6-Chloro-7-(trifluoromethyl)chroman-4-one (CAS 1092349-68-2)
- 3-Chloro-4-(trifluoromethyl)cinnamic acid (CAS 1092460-80-4)
- (8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)methanol (CAS 1216024-49-5)
- 6-Chloro-8-(trifluoromethyl)chroman-4-one (CAS 1344889-75-3)
- (E)-3-(2-Chloro-5-(trifluoromethyl)phenyl)acrylic acid (CAS 1386504-00-2)
Recommended Standards
- 3-(2-Chloropyrimidin-5-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole (CAS 1433206-26-8)
- Quinazoline, 4-chloro-6-fluoro-2-(trifluoromethyl)- (CAS 959238-11-0)
- 3-Chloro-4-cyano-5-(trifluoromethyl)picolinic acid (CAS 1221791-55-4)
- 4-(Difluoromethyl)-6-methyl-3-nitropicolinoyl chloride (CAS 1804881-95-5)
- 4-(Chloromethyl)-6-hydroxypicolinaldehyde (CAS 1393551-36-4)
- [(e)-2-nitroethenyl]cyclohexane (CAS 132839-80-6)
- Sodium carboxymethylstearylhydroxy-ethyl imidazolinium hydro (CAS 68608-63-9)
- 3,3,3-Trifluoro-2-hydroxy-2-(m-tolyl)propanoic acid (CAS 81182-31-2)
- 5-fluoro-3-methyl-3H-isobenzofuran-1-one (CAS 2231233-89-7)
- 6-Phenylimidazo[1,2-a]pyridine-2-carboxylic acid (CAS 1173694-02-4)
- 2-Chloro-3-fluoro-4-methoxy-1-nitrobenzene (CAS 1936126-55-4)
- 5-Phenyl-1-(3-phenylpropyl)pyrimidine-2,4(1H,3H)-dione (CAS 13345-02-3)
- 2-(3-Bromo-5-methyl-phenylsulfanyl)-ethanol (CAS 1824056-44-1)
- D-Phe22-Tirzepatide (CAS CATO-CPTD788912)
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