Clobetasol Propionate EP Impurity I CAS 15423-80-0
| CAS No. | 15423-80-0 |
| Molecular Formula | C26H35FO8S |
| Molecular Weight | 526.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Clobetasol Propionate EP Impurity I (CAS 15423-80-0), a pharmacopoeial impurity reference standard (molecular formula C26H35FO8S, MW 526.61 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Clobetasol Propionate EP Impurity I (C26H35FO8S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 526.61 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H35FO8S |
| Molecular Weight | 526.61 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Clobetasol Standards
- Clobetasol Propionate Impurity 22 (CAS CATO-C4X-159222)
- Clobetasol butyrate (CAS 25122-47-8)
- Clobetasol 17-Propionate-d5 (CAS CATO-CCAD302397)
- Clobetasol Propionate EP Impurity D (CAS 25120-99-4)
- Clobetasol Propionate EP Impurity C (CAS 25122-52-5)
- Clobetasol Propionate (CAS 25122-46-7)
- Clobetasol Propionate Impurity 21 (CAS CATO-C4X-159221)
- Clobetasol Propionate Impurity (21-Chloro-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione) (CAS 95796-50-2)
Recommended Standards
- 6-[(E)-2-(4-Methylphenyl)ethenyl]-4-[(Z)-2-(4-methylphenyl)ethenyl]-2-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)pyridine-3-carbonitrile (CAS 303985-30-0)
- Iganidipine (CAS 119687-33-1)
- 4-Fluoro-N-(1-(5-((4-fluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-2-phenylethyl)benzamide (CAS 478066-91-0)
- (R)-2,2'-Bis(methoxymethoxy)-3,3'-diphenyl-1,1'-binaphthalene (CAS 428874-67-3)
- Arotinolol Impurity 15 (CAS CATO-C4X-185415)
- Ixazomib Impurity 88 (CAS CATO-C4X-126788)
- Oseltamivir Impurity 25 (CAS 1132659-98-3)
- 2-Neopentylpiperidine (CAS 383128-30-1)
- 1,3-Isobenzofurandione, polymer with 2,2-bis(hydroxymethyl)-1,3-propanediol and oxybis[propanol] (CAS 68123-20-6)
- 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine Hydrochloride (CAS 766545-20-4)
- 1-Bromo-2-cyclopropoxy-4-(methylsulfonyl)benzene (CAS 1403330-00-6)
- (2S,3S,4S,5R,6S)-4-(((2S,3R,4S,5S,6R)-3-Acetoxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-((5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl acetate (CAS 174286-23-8)
- 3-(2-Methylbenzo[d]oxazol-5-yl)propanenitrile (CAS 61309-77-1)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
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