Clobetasol butyrate CAS 25122-47-8
| CAS No. | 25122-47-8 |
| Molecular Formula | C26H34ClFO5 |
| Molecular Weight | 481.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Clobetasol butyrate (CAS 25122-47-8), a certified reference material (molecular formula C26H34ClFO5, MW 481.00 g/mol) for analytical method development and quality control.
Based on its molecular formula C26H34ClFO5, Clobetasol butyrate contains a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 481.00 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Clobetasol butyrate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H34ClFO5 |
| Molecular Weight | 481.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F/Cl-containing |
Related Clobetasol Standards
- Clobetasol 17-Propionate-d5 (CAS CATO-CCAD302397)
- Clobetasol Propionate EP Impurity D (CAS 25120-99-4)
- Clobetasol Propionate EP Impurity C (CAS 25122-52-5)
- Clobetasol Propionate (CAS 25122-46-7)
- Clobetasol Propionate Impurity (21-Chloro-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione) (CAS 95796-50-2)
- Clobetasol Propionate EP Impurity J (CAS 1486466-31-2)
- Clobetasol Propionate Impurity 19 (CAS CATO-C4X-159219)
- Clobetasol Propionate EP Impurity A (CAS 5534-13-4)
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