Clobetasol Propionate EP Impurity D CAS 25120-99-4

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.25120-99-4
Molecular FormulaC25H34ClFO5
Molecular Weight468.99 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Clobetasol Propionate EP Impurity D CAS 25120-99-4 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clobetasol Propionate EP Impurity D.

CATO supplies Clobetasol Propionate EP Impurity D (CAS 25120-99-4), a pharmacopoeial impurity reference standard (molecular formula C25H34ClFO5, MW 468.99 g/mol) used for the identification and quantification of trace impurities in APIs.

Based on its molecular formula C25H34ClFO5, Clobetasol Propionate EP Impurity D contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 468.99 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC25H34ClFO5
Molecular Weight468.99 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1964
Halogen ContentF/Cl-containing

Related Clobetasol Standards

Recommended Standards

Why CATO?