2-Chloro-5-Fluoropyrimidin-4(3H)-One CAS 155-12-4
| CAS No. | 155-12-4 |
| Molecular Formula | C4H2ClFN2O |
| Molecular Weight | 148.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-Fluoropyrimidin-4(3H)-One (CAS 155-12-4) is a high-purity analytical reference standard with the molecular formula C4H2ClFN2O and a molecular weight of 148.52 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 2-Chloro-5-Fluoropyrimidin-4(3H)-One is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 148.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-5-Fluoropyrimidin-4(3H)-One meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H2ClFN2O |
| Molecular Weight | 148.52 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 6-Chloro-5-fluoropyrimidin-4(1H)-one (CAS 1805161-90-3)
- 2-Chloro-6-fluoropyrimidin-4-ol (CAS 1805225-46-0)
- 4-Chloro-6-fluoropyrimidin-5-ol (CAS 1805639-49-9)
- 2-Chloro-4-fluoropyrimidin-5-ol (CAS 1807115-17-8)
- 1-Chloro-2-(trifluoromethoxy)ethane (CAS 1645-95-0)
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- 1-Chloro-3,5-difluorobenzene (CAS 1435-43-4)
Recommended Standards
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