Abemaciclib Impurity 27 CAS 22462-34-6

Purity >50%In StockPharmacopoeial Impurity Standards
CAS No.22462-34-6
Molecular FormulaC4H2ClFN2O
Molecular Weight148.52 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Abemaciclib Impurity 27 CAS 22462-34-6 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Abemaciclib Impurity 27.

CATO supplies Abemaciclib Impurity 27 (CAS 22462-34-6), a pharmacopoeial impurity reference standard (molecular formula C4H2ClFN2O, MW 148.52 g/mol) used for the identification and quantification of trace impurities in APIs.

Based on its molecular formula C4H2ClFN2O, Abemaciclib Impurity 27 contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 148.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

CATO manufactures Abemaciclib Impurity 27 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC4H2ClFN2O
Molecular Weight148.52 g/mol
Purity>50%
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1963
Halogen ContentF/Cl-containing
Nitrogen Atoms2

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