Cyclophosphamide EP Impurity E DiHCl CAS 158401-51-5
| CAS No. | 158401-51-5 |
| Molecular Formula | C7H18ClN2O4P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Cyclophosphamide EP Impurity E DiHCl (C7H18ClN2O4PHCl) contains an amide group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of -1.5, corresponding to approximately 0 ring(s) or double-bond equivalent(s). With a molecular weight of 297.11 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Cyclophosphamide EP Impurity E DiHCl (CAS 158401-51-5) is a certified pharmaceutical impurity reference standard with the molecular formula C7H18ClN2O4PHCl and a molecular weight of 297.11 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H18ClN2O4P 2*HCl |
| Molecular Weight | 297.11 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | -1.5 |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cyclophosphamide Standards
- Cyclophosphamide EP Impurity F (CAS 1071-28-9)
- Cyclophosphamide-d8 (CAS 1178903-96-2)
- Cyclophosphamide Impurity 13 (CAS 127-88-8)
- Cyclophosphamide Impurity 23 (CAS 1361416-62-7)
- Cyclophosphamide EP Impurity D (CAS 158401-52-6)
- Cyclophosphamide EP Impurity A (CAS 1797009-12-1)
- Cyclophosphamide Impurity 14 (CAS 18907-76-1)
- Cyclophosphamide Impurity 19 (CAS 22089-17-4)
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