Niraparib Impurity 49 CAS 1267209-15-3
| CAS No. | 1267209-15-3 |
| Molecular Formula | C11H14BrNO2 |
| Molecular Weight | 272.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 272.14 g/mol gives Niraparib Impurity 49 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Niraparib Impurity 49 (CAS 1267209-15-3) is a certified pharmaceutical impurity reference standard with the molecular formula C11H14BrNO2 and a molecular weight of 272.14 g/mol.
Based on its molecular formula C11H14BrNO2, Niraparib Impurity 49 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 272.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14BrNO2 |
| Molecular Weight | 272.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Niraparib Standards
- Niraparib Impurity 60 (CAS CATO-C4X-232960)
- Niraparib Impurity 61 (CAS 3112957-16-8)
- Niraparib Impurity 64 (CAS 2820493-80-7)
- Niraparib Impurity 65 (CAS CATO-C4X-232965)
- Niraparib Impurity 21 (CAS 1263284-59-8)
- Niraparib Impurity 3 (CAS 1171197-20-8)
- Niraparib Impurity 35 (CAS 1524736-92-2)
- Niraparib Impurity 53 (CAS 1584236-54-3)
Recommended Standards
- Losartan Impurity 43 (CAS 135689-84-8)
- N-Methyl-4,6-bis(trifluoromethyl)pyridine-2-carboxamide (CAS 1092344-91-6)
- Losartan Impurity 42 (CAS 2901098-91-5)
- 2,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (CAS 1111637-99-0)
- Fluticasone Furoate EP Impurity A (CAS 397864-63-0)
- Amikacin Impurity 21 (CAS 40371-54-8)
- Propofol Impurity 44 (CAS 83420-68-2)
- 4-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 212268-44-5)
- 8-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline (CAS 2813233-26-8)
- 1-Ethyl-2-piperazinone hydrochloride (CAS 873221-66-0)
- (R)-(4-Chlorophenyl)(cyclopropyl)methanamine (CAS 1212934-73-0)
- 4-Bromo-3-chloro-1H-indazol-6-ol (CAS 887568-89-0)
- tert-Butyl 3-(2-(4-fluorophenyl)acetyl)benzylcarbamate (CAS 1017781-73-5)
- (Met(O)2?)-Glucagon (1-29) (human, rat, porcine) (CAS 75217-63-9)
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