Triamcinolone Acetonide Impurity 53 CAS 61618-63-1
| CAS No. | 61618-63-1 |
| Molecular Formula | C21H25FO4 |
| Molecular Weight | 360.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Triamcinolone Acetonide Impurity 53 (CAS 61618-63-1), a pharmacopoeial impurity reference standard (molecular formula C21H25FO4, MW 360.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Triamcinolone Acetonide Impurity 53 (C21H25FO4) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25FO4 |
| Molecular Weight | 360.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | F-containing |
Related Triamcinolone Standards
- Triamcinolone Acetonide Impurity 36 (CAS 159210-07-8)
- Triamcinolone Acetonide Impurity 8 (Pretriamcinolone) (CAS CATO-C4X-13268)
- Triamcinolone Acetonide Impurity 39 (CAS 85197-66-6)
- Triamcinolone Acetonide Impurity 43 (CAS CATO-C4X-132643)
- Triamcinolone Acetonide EP Impurity A (CAS 124-94-7)
- Triamcinolone EP Impurity C (CAS 337-02-0)
- Triamcinolone Impurity 10 (CAS 3800-28-0)
- Triamcinolone Acetonide Impurity N2 (CAS 1893-84-1)
Recommended Standards
- Dexamethasone Impurity 94 (CAS 59861-00-6)
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- Pranlukast Impurity 8 (CAS CATO-C4X-18048)
- Teneligliptin Impurity 53 (CAS 1572583-27-7)
- Valganciclovir Impurity 32 (CAS 960582-59-6)
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