Irinotecan EP Impurity H CAS 1608617-71-5
| CAS No. | 1608617-71-5 |
| Molecular Formula | C32H36N4O6 |
| Molecular Weight | 572.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Irinotecan EP Impurity H (CAS 1608617-71-5, C32H36N4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Irinotecan EP Impurity H (C32H36N4O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 572.65 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Irinotecan EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H36N4O6 |
| Molecular Weight | 572.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 4 |
Related Irinotecan Standards
- Irinotecan Impurity 51 (CAS 2944102-98-9)
- Irinotecan Impurity 38 (CAS 143490-54-4)
- Irinotecan EP Impurity A (CAS 103816-16-6)
- Irinotecan (CAS 97682-44-5)
- Irinotecan EP Impurity L (CAS 1255644-71-3)
- Irinotecan Lactone Impurity (CAS 143490-53-3)
- Irinotecan Impurity 29 (CAS CATO-C4X-166729)
- Irinotecan Impurity 28 (CAS CATO-C4X-166728)
Recommended Standards
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- Ubenimex Impurity 9 (CAS CATO-C4X-18529)
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- Omacycline impurity 10 (CAS CATO-C4X-285710)
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