Furosemide EP Impurity F CAS 4793-38-8
| CAS No. | 4793-38-8 |
| Molecular Formula | C12H15ClN2O5S |
| Molecular Weight | 334.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Furosemide EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Furosemide EP Impurity F (CAS 4793-38-8) is a certified pharmaceutical impurity reference standard with the molecular formula C12H15ClN2O5S and a molecular weight of 334.78 g/mol.
Structurally, Furosemide EP Impurity F (C12H15ClN2O5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 334.78 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H15ClN2O5S |
| Molecular Weight | 334.78 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 54 (CAS 33069-75-9)
- Furosemide Impurity 48 Sodium Salt (CAS 133989-65-8（free base）)
- Furosemide-d5 (CAS 1189482-35-6)
- Furosemide Impurity 25 (CAS 2309462-39-1)
- Furosemide Impurity 47 (CAS CATO-C4X-140247)
- Furosemide Impurity 9 (CAS CATO-C4X-14029)
- Furosemide (CAS 54-31-9)
- Furosemide EP Impurity A (CAS 4818-59-1)
Recommended Standards
- Ethyl 4-(benzyloxy)-3-chloro-5-ethoxybenzoate (CAS 1706463-34-4)
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- Methyl 2-deoxy-2-fluoro-b-D-glucopyranoside (CAS 39110-58-2)
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- Mirogabalin Impurity 42 (CAS 1138245-50-7)
- 3-Bromoadamantane-1-carboxamide (CAS 53263-89-1)
- 6-Hydrazinyl-n-(pyridin-2-yl)pyridine-3-sulfonamide (CAS 926198-15-4)
- 1-Benzyl-5-methyl-3-nitro-1h-pyrazole (CAS 898053-54-8)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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