Neostigmine Impurity 25 CAS 76418-45-6
| CAS No. | 76418-45-6 |
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Neostigmine Impurity 25 (CAS 76418-45-6) is a certified pharmaceutical impurity reference standard with the molecular formula C10H14N2O2 and a molecular weight of 194.23 g/mol.
Based on its molecular formula C10H14N2O2, Neostigmine Impurity 25 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 194.23 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 2 |
Related Neostigmine Standards
- Neostigmine impurity 34 (CAS CATO-C4X-204234)
- Neostigmine impurity 36 (CAS CATO-C4X-204236)
- Neostigmine impurity 38 (CAS CATO-C4X-204238)
- Neostigmine impurity 01 (CAS 618-09-7)
- Neostigmine impurity 35 (CAS CATO-C4X-204235)
- Neostigmine Impurity 26 (CAS 4849-46-1)
- Neostigmine impurity 37 (CAS CATO-C4X-204237)
- Neostigmine EP Impurity C (CAS 16088-19-0)
Recommended Standards
- Methoxamine Impurity 6 (CAS 1835-04-7)
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- Metaraminol Impurity 16 (CAS 37951-47-6)
- Linagliptin Impurity 49 (CAS CATO-C4X-110149)
- Peramivir Impurity 18 (CAS CATO-C4X-183318)
- O-(4-(1H-Pyrazol-1-yl)benzyl)hydroxylamine (CAS 628703-38-8)
- 5-Benzylidene-3-phenylimidazo[2,1-b]thiazol-6(5H)-one (CAS 89990-78-3)
- 2-(Pyridin-2-yl)morpholine hydrochloride (CAS 1251023-51-4)
- 1-(5-Chloro-2-methoxyphenyl)butan-1-one (CAS 219922-62-0)
- 1-Methyl-3-(trifluoromethoxy)benzene (CAS 705-44-2)
- Benzyl (R)-2-methyl-5-oxopiperidine-1-carboxylate (CAS 1616434-59-3)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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