Dapagliflozin Impurity 149 CAS 1616259-14-3
| CAS No. | 1616259-14-3 |
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 450.91 g/mol gives Dapagliflozin Impurity 149 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Dapagliflozin Impurity 149 (CAS 1616259-14-3, C23H27ClO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dapagliflozin Impurity 149 (C23H27ClO7) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dapagliflozin Impurity 149 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 159 (CAS CATO-C4X-1138159)
- Dapagliflozin Impurity 160 (CAS CATO-C4X-1138160)
- Dapagliflozin Impurity 191 (CAS 1616259-44-9)
- Dapagliflozin Impurity 4 (CAS 1632287-34-3)
- Dapagliflozin Impurity 117 (CAS 2377899-45-9)
- Dapagliflozin Impurity 135 (CAS CATO-C4X-1138135)
- Dapagliflozin 4-Bromo Analog (CAS 1807632-95-6)
- Dapagliflozin Impurity 118 (CAS CATO-C4X-1138118)
Recommended Standards
- Empagliflozin Impurity 6 (CAS CATO-C4X-10656)
- Empagliflozin Impurity 53 (CAS CATO-C4X-106553)
- Empagliflozin Impurity 5 (CAS 1620758-33-9)
- Empagliflozin Impurity 37 (CAS 2452301-30-1)
- Dicycloverine EP Impurity A (CAS 60263-54-9)
- Letermovir Impurity 8 (CAS CATO-C4X-29158)
- Tedizolid Impurity 41 (CAS CATO-C4X-105441)
- Ozagrel Impurity 48 (CAS 66885-68-5)
- (R)-2-((tert-Butoxycarbonyl)amino)-3-(2,3-dichloro-4-hydroxyphenyl)propanoic acid (CAS 1213953-15-1)
- 1-(2-(Dimethylamino)ethyl)-1H-indole-3-carbaldehyde (CAS 100615-20-1)
- 5-Cyclopropoxy-N-methyl-2-sulfamoylnicotinamide (CAS 1243474-21-6)
- 2-Hydroxy-2,3-dihydro-1H-inden-1-one (CAS 1579-16-4)
- Ethyl 3-azabicyclo[3.1.0]Hexane-2-carboxylate (CAS 75715-99-0)
- Tau Peptide (379-408) trifluoroacetate salt (CAS 1246357-53-8)
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