Dapagliflozin Impurity 117 CAS 2377899-45-9
| CAS No. | 2377899-45-9 |
| Molecular Formula | C22H25ClO8 |
| Molecular Weight | 452.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Dapagliflozin Impurity 117 (CAS 2377899-45-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H25ClO8 and a molecular weight of 452.88 g/mol.
Structurally, Dapagliflozin Impurity 117 (C22H25ClO8) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 452.88 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H25ClO8 |
| Molecular Weight | 452.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 135 (CAS CATO-C4X-1138135)
- Dapagliflozin 4-Bromo Analog (CAS 1807632-95-6)
- Dapagliflozin Impurity 149 (CAS 1616259-14-3)
- Dapagliflozin Impurity 159 (CAS CATO-C4X-1138159)
- Dapagliflozin Impurity 160 (CAS CATO-C4X-1138160)
- Dapagliflozin Impurity 191 (CAS 1616259-44-9)
- Dapagliflozin Impurity 4 (CAS 1632287-34-3)
- Dapagliflozin Impurity 118 (CAS CATO-C4X-1138118)
Recommended Standards
- N-(4-chloro-3-(trifluoromethyl)phenyl)-2-((7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)thio)acetamide (CAS 728888-23-1)
- Ertugliflozin impurity 22 (CAS 1298086-28-8)
- 7-(4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-4-methyl-2-(methylthio)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (CAS 338416-24-3)
- Ertugliflozin Impurity 50 (CAS 1298086-33-5)
- Clotrimazole EP Impurity C (CAS 42074-68-0)
- Canagliflozin Impurity 64 (CAS CATO-C4X-112364)
- Betahistine Impurity 5 (CAS 6293-56-7)
- tert-Butyl (1-(2-aminoethyl)pyrrolidin-3-yl)(ethyl)carbamate (CAS 1353974-61-4)
- (4,8-Dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)boronic acid (CAS 202824-51-9)
- Methyl 3-(2-(allylcarbamoyl)-1H-pyrrol-1-yl)thiophene-2-carboxylate (CAS 477863-85-7)
- 3-Aminobenzofuran-2-carbonitrile (CAS 62208-67-7)
- 5-Bromo-4-fluoro-2-(trifluoromethoxy)aniline (CAS 1807212-78-7)
- 9-Methyldecanoic acid (CAS 1119-63-7)
- [3-31]-Semaglutide D (Sodium salt) (CAS CATO-C4X-2226119)
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