Fosaprepitant Impurity 48 CAS 1707-92-2
| CAS No. | 1707-92-2 |
| Molecular Formula | C21H21O4P |
| Molecular Weight | 368.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Fosaprepitant Impurity 48 (CAS 1707-92-2) is a certified pharmaceutical impurity reference standard with the molecular formula C21H21O4P and a molecular weight of 368.36 g/mol.
The molecular framework of Fosaprepitant Impurity 48 (C21H21O4P) is characterized by a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fosaprepitant Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H21O4P |
| Molecular Weight | 368.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 30 (CAS 327623-37-0)
- Fosaprepitant Impurity 16 (CAS 327623-34-7)
- Fosaprepitant Impurity 49（Racemate） (CAS CATO-C4X-116849)
- Fosaprepitant Impurity 59 (CAS CATO-C4X-116859)
- Fosaprepitant Impurity 874 (CAS 538-37-4)
- Fosaprepitant Impurity 37 (CAS CATO-C4X-116837)
- Fosaprepitant Impurity 53 (CAS 1254261-32-9)
- Fosaprepitant Impurity 41 (CAS 287930-73-8)
Recommended Standards
- Regorafenib Impurity 19 (CAS 2098799-12-1)
- 4-Isopropylphenyl Diphenyl Phosphate (CAS 55864-04-5)
- 1,3,6-naphthalenetrisulfonic acid 86-66-8 CHEBI:32916 naphthalene-1,3,6-trisulfonic acid naphthalene-1,3,6-trisulphonic acid (CAS 86-66-8)
- Tricresyl Phosphate(mixture of isomers) (CAS 1330-78-5)
- Celecoxib Impurity 49 (CAS 720-94-5)
- Pivmecillinam Impurity 10 (CAS CATO-C4X-232310)
- Cefuroxime Impurity 61 (CAS CATO-C4X-124561)
- 4-Ethyl-2-methoxypyridine (CAS 98593-17-0)
- 3-methyl-5-phenylcyclohexan-1-one (CAS 60741-75-5)
- 1-(1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)cyclopropan-1-amine (CAS 1159734-02-7)
- 2-Bromo-5-(pyrrolidine-1-sulfonyl)benzoic acid (CAS 22361-65-5)
- 1,3,5-Tribromo-2-(difluoromethoxy)benzene (CAS 920981-13-1)
- 3-Amino-1-(4-fluorophenyl)butan-1-one hydrochloride (CAS 1394041-57-6)
- Cycloaspeptide D (CAS 691363-62-9)
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