Roflumilast Impurity 4 CAS 162401-30-1
| CAS No. | 162401-30-1 |
| Molecular Formula | C14H8Cl2F4N2O3 |
| Molecular Weight | 399.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Roflumilast Impurity 4 (CAS 162401-30-1) is a certified pharmaceutical impurity reference standard with the molecular formula C14H8Cl2F4N2O3 and a molecular weight of 399.12 g/mol.
Roflumilast Impurity 4 (C14H8Cl2F4N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8Cl2F4N2O3 |
| Molecular Weight | 399.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast (CAS 162401-32-3)
- Roflumilast Impurity 1 (CAS 162401-43-6)
- Roflumilast Impurity 29 (CAS 2368178-28-1)
- Roflumilast Impurity 53 (CAS 2204417-23-0)
- Roflumilast-d3 (CAS 1189992-00-4)
- Roflumilast -D4 (CAS 1398065-69-4)
- Roflumilast Impurity 6 (CAS 2368178-29-2)
- Roflumilast Impurity 3 (CAS 1391052-24-6)
Recommended Standards
- Elagolix Impurity 115 (CAS CATO-C4X-2068115)
- (3-Amino-2,6-difluorophenyl)(5-iodo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone (CAS 1254567-35-5)
- Elagolix Impurity 112 (CAS CATO-C4X-2068112)
- 1-((3-Bromophenoxy)methyl)-3,5-bis(trifluoromethyl)benzene (CAS 845866-55-9)
- Sultamicillin EP Impurity F (CAS CATO-C4X-18866)
- Enoxacin Impurity 8 (CAS 115274-26-5)
- Levetiracetam Impurity 12 (CAS 103765-03-3)
- 2-(Imino(phenyl)methyl)aniline (CAS 5606-41-7)
- 3α-Aminocholestane Hydrochloride (CAS 5457-79-4)
- (1-Benzyl-2-{[(4-chlorophenyl)methyl]sulfanyl}-1H-imidazol-5-yl)methanol (CAS 478031-84-4)
- [1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]methanol (CAS 111340-39-7)
- (2E)-1-(3-Bromophenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one (CAS 1287257-13-9)
- 2-Butoxy-3-chloro-5-methylpyridine (CAS 1881331-15-2)
- Custom peptides (CAS CATO-CPTD788509)
Why CATO?
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