Roflumilast Impurity 29 CAS 2368178-28-1
| CAS No. | 2368178-28-1 |
| Molecular Formula | C17H14Cl2F2N2O3 |
| Molecular Weight | 403.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 403.21 g/mol gives Roflumilast Impurity 29 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Roflumilast Impurity 29 (CAS 2368178-28-1, C17H14Cl2F2N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Roflumilast Impurity 29 (C17H14Cl2F2N2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Roflumilast Impurity 29 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H14Cl2F2N2O3 |
| Molecular Weight | 403.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast (CAS 162401-32-3)
- Roflumilast Impurity 1 (CAS 162401-43-6)
- Roflumilast Impurity 53 (CAS 2204417-23-0)
- Roflumilast-d3 (CAS 1189992-00-4)
- Roflumilast -D4 (CAS 1398065-69-4)
- Roflumilast Impurity 6 (CAS 2368178-29-2)
- Roflumilast Impurity 3 (CAS 1391052-24-6)
- Roflumilast Impurity 4 (CAS 162401-30-1)
Recommended Standards
- 4-Dechloro-4-hydroxy Diclazuril Methyl Ester (CAS 1101258-51-8)
- Tributyl(5-methoxythiophen-2-yl)stannane (CAS 879480-43-0)
- N-((4-bromo-2-(trifluoromethyl)phenyl)carbamothioyl)benzamide (CAS 887266-94-6)
- Diethyl 2-(((4-iodo-2-methylphenyl)-amino)methylene)malonate (CAS 951006-38-5)
- Tranexamic Acid EP Impurity C (CAS 330838-52-3)
- Dotinurad Impurity 187 (CAS CATO-C4X-2494187)
- Brexpiprazole Impurity 167 (CAS CATO-C4X-1131167)
- H-D-Ser(SO3H)-OH (F-3370.0001) (CAS 19794-48-0)
- Methyl 5-chloro-2,3-dihydroxybenzoate (CAS 278805-36-0)
- 2-(3,5-Difluorophenyl)-2-methylpropanoic acid (CAS 879904-44-6)
- 2-(Tetrahydrofuran-3-yl)nicotinic acid (CAS 1823548-22-6)
- 2-(2-Bromo-4,5-dimethylphenoxy)acetamide (CAS 1706444-01-0)
- 1,2-Dichloro-4-(3-nitrophenyl)benzene (CAS 1365271-51-7)
- [D-Phe22]Semaglutide (CAS CATO-C4X-2226222)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com