Atorvastatin impurity 159 CAS 163217-75-2
| CAS No. | 163217-75-2 |
| Molecular Formula | C33H36FN2O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Atorvastatin impurity 159 (CAS 163217-75-2) is a certified pharmaceutical impurity reference standard with the molecular formula C33H36FN2O6Na and a molecular weight of 598.65 g/mol.
Atorvastatin impurity 159 (C33H36FN2O6Na) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Atorvastatin impurity 159 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H36FN2O6 Na |
| Molecular Weight | 598.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 22 (CAS 1035205-25-4)
- Atorvastatin Calcium Propylene Glycol Solvate (CAS 1040350-07-9)
- Atorvastatin Lactone Diepoxide (CAS 1046118-40-4)
- Atorvastatin Lactam calcium Salt Impurity (CAS 1046118-41-5)
- Atorvastatin Impurity 86 (CAS 1046118-44-8)
- Atorvastatin Impurity 141 Calcium Salt (CAS 1046378-58-8)
- Atorvastatin Impurity 76 (CAS 1099474-28-8)
- Atorvastatin EP Impurity F(Calcium Salt) (CAS 1105067-87-5)
Recommended Standards
- Olopatadine Impurity 70 (CAS CATO-C4X-171870)
- Acyclovir Impurity 31 (CAS CATO-C4X-101031)
- Deferiprone Impurity 6 (CAS CATO-C4X-30486)
- N-(2-Aminoethyl)methacrylamide (CAS 63298-57-7)
- Policresulen Impurity 6 (CAS 17688-83-4)
- 6-Methoxyphthalazin-1-ol (CAS 60889-21-6)
- Methyl 1,4-Diazepane-2-carboxylate (CAS 1219532-80-5)
- N-(3-Hydroxy-5-iodophenyl)methanesulfonamide (CAS 1243391-36-7)
- 5'-Fluoro-N-phenyl-[1,1':3',1''-terphenyl]-4'-amine (CAS 1228153-91-0)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
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