Ibrutinib Impurity 192 CAS 1633351-79-7
| CAS No. | 1633351-79-7 |
| Molecular Formula | C27H30ClN5O3 |
| Molecular Weight | 508.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ibrutinib Impurity 192 (CAS 1633351-79-7, C27H30ClN5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ibrutinib Impurity 192 (C27H30ClN5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ibrutinib Impurity 192 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H30ClN5O3 |
| Molecular Weight | 508.01 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Ibrutinib Standards
- Ibrutinib Impurity 29 (CAS CATO-C4X-106429)
- Ibrutinib Impurity 127 (CAS CATO-C4X-1064127)
- Ibrutinib Impurity 17 (CAS CATO-C4X-106417)
- Ibrutinib Impurity 50 (CAS CATO-C4X-106450)
- Ibrutinib Impurity 9 (CAS CATO-C4X-10649)
- Ibrutinib Impurity N11 (CAS 2244619-11-0)
- Ibrutinib Impurity 162 (CAS CATO-C4X-1064162)
- Ibrutinib Impurity 133 (CAS CATO-C4X-1064133)
Recommended Standards
- cis-Clopidogrel-MP Derivative 13CD3 (CAS CATO-C4X-102966)
- Osimertinib-4 (CAS 1805787-93-2)
- Clopidogrel Impurity 92-13C,d3 (CAS CATO-C4X-1029129)
- Ribociclib Impurity 20 (CAS CATO-C4X-310020)
- Indacaterol Impurity 71 (CAS CATO-C4X-150071)
- Fosfomycin Impurity 71 (CAS CATO-C4X-131671)
- Apremilast Impurity 57 (CAS 1255909-25-1)
- 4-Chloro-5-methoxy-1-methyl-1H-pyrazole-3-carboxylic acid (CAS 1239759-59-1)
- 3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-(p-tolyl)-1H-pyrazole-4-carbaldehyde (CAS 618098-94-5)
- 1-(2,5-Difluorophenyl)ethane-1-sulfonyl chloride (CAS 1249028-29-2)
- (R)-1-(3-(trifluoromethoxy)phenyl)but-3-en-1-amine (CAS 1270119-24-8)
- 5-Chloro-4-methoxypicolinonitrile (CAS 1261733-88-3)
- 4-Allyl-2-chloropyridine (CAS 219727-28-3)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
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