Ibrutinib Impurity 29 CAS CATO-C4X-106429
| CAS No. | CATO-C4X-106429 |
| Molecular Formula | C27H29ClN6O2 |
| Molecular Weight | 505.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ibrutinib Impurity 29.
As a process- or degradation-related impurity, Ibrutinib Impurity 29 (CAS CATO-C4X-106429, C27H29ClN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ibrutinib Impurity 29 (C27H29ClN6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 505.01 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H29ClN6O2 |
| Molecular Weight | 505.01 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 127 (CAS CATO-C4X-1064127)
- Ibrutinib Impurity 192 (CAS 1633351-79-7)
- Ibrutinib Impurity 133 (CAS CATO-C4X-1064133)
- Ibrutinib Impurity 128 (CAS 2190506-56-8)
- Ibrutinib Impurity 139 (CAS CATO-C4X-1064139)
- Ibrutinib Impurity 17 (CAS CATO-C4X-106417)
- Ibrutinib Impurity 50 (CAS CATO-C4X-106450)
- Ibrutinib Impurity 9 (CAS CATO-C4X-10649)
Recommended Standards
- 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide (CAS 288250-47-5)
- 4-Chloro-N-((2,3-diphenylisoxazolidin-5-yl)methyl)-N-phenylbenzenesulfonamide (CAS 306978-07-4)
- N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide (CAS 1191911-27-9)
- Dysprosium(III) carbonate (CAS 5066-34-2)
- Pitolisant Impurity 49 (CAS CATO-C4X-252049)
- Nebivolol Impurity 35 (CAS 1199945-26-0)
- Docetaxel Impurity 62 (CAS CATO-C4X-161962)
- 6,8-Dimethyl-2-(4-propylphenyl)quinoline-4-carbonyl chloride (CAS 1160255-01-5)
- N-(Pyrimidin-4-yl)acetamide (CAS 16166-22-6)
- 2-(2-Methoxyphenyl)-1H-imidazo[4,5-b]pyridine (CAS 53929-99-0)
- {[4-(Methylsulfanyl)phenyl]methyl}(prop-2-en-1-yl)amine (CAS 893591-69-0)
- 2-(2,5-Dichlorophenyl)-4-oxo-1,4-dihydroquinoline-6-carboxylic acid (CAS 90034-23-4)
- 4-Chloro-8-cyclobutylpteridine-6,7(5H,8H)-dione (CAS 1774904-50-5)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
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