Ibrutinib Impurity 9 CAS CATO-C4X-10649
| CAS No. | CATO-C4X-10649 |
| Molecular Formula | C28H28N6O4 |
| Molecular Weight | 512.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Ibrutinib Impurity 9 (CAS CATO-C4X-10649), a pharmacopoeial impurity reference standard (molecular formula C28H28N6O4, MW 512.56 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ibrutinib Impurity 9 (C28H28N6O4) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C28H28N6O4 |
| Molecular Weight | 512.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 17 (CAS CATO-C4X-106417)
- Ibrutinib Impurity 50 (CAS CATO-C4X-106450)
- Ibrutinib Impurity N11 (CAS 2244619-11-0)
- Ibrutinib Impurity 162 (CAS CATO-C4X-1064162)
- Ibrutinib Impurity 192 (CAS 1633351-79-7)
- Ibrutinib Impurity 29 (CAS CATO-C4X-106429)
- Ibrutinib Impurity 141 (CAS CATO-C4X-1064141)
- Ibrutinib Impurity 127 (CAS CATO-C4X-1064127)
Recommended Standards
- Azilsartan Impurity 103 (CAS CATO-C4X-1096103)
- Azilsartan Impurity 79 (CAS 1613135-56-0)
- Elastatinal (CAS 51798-45-9)
- Almorexant (αS,1S) Isomer (CAS 2055114-67-3)
- Piperacillin Monohydrate EP Impurity N (CAS CATO-C4X-173219)
- Ornidazole Impurity 39 (CAS 1064004-83-6)
- Digoxin EP Impurity A (CAS 71-63-6)
- (2,4,6-Tripropoxyphenyl)boronic acid (CAS 917981-29-4)
- 1-(3-Fluorophenyl)-N,N-dimethylmethanamine (CAS 770-18-3)
- N-(3,4-dimethoxybenzyl)-4-methoxyaniline (CAS 82376-73-6)
- 3-Amino-N-(4-methoxyphenyl)propanamide (CAS 770652-56-7)
- 3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-(10h-phenothiazin-10-yl)propan-1-one dihydrochloride 30379-54-5 AR-1F1023 (CAS 30379-54-5)
- Hexahydropyrrolo[2,1-b]oxazole-5-carbonitrile (CAS 256937-90-3)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com