Ibrutinib Impurity 133 CAS CATO-C4X-1064133
| CAS No. | CATO-C4X-1064133 |
| Molecular Formula | C27H28N6O4 |
| Molecular Weight | 500.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Ibrutinib Impurity 133 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 500.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Ibrutinib Impurity 133 (CAS CATO-C4X-1064133) is a certified pharmaceutical impurity reference standard with the molecular formula C27H28N6O4 and a molecular weight of 500.55 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H28N6O4 |
| Molecular Weight | 500.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 128 (CAS 2190506-56-8)
- Ibrutinib Impurity 139 (CAS CATO-C4X-1064139)
- Ibrutinib Impurity 127 (CAS CATO-C4X-1064127)
- Ibrutinib Impurity 29 (CAS CATO-C4X-106429)
- Ibrutinib Impurity 126 (CAS 2190506-55-7)
- Ibrutinib Impurity 108 (CAS CATO-C4X-1064108)
- Ibrutinib Impurity 11 (CAS 2031255-27-1)
- Ibrutinib Impurity 19 (CAS 1917333-91-5)
Recommended Standards
- Travoprost Enantiomer (CAS 340181-93-3)
- Dabigatran Impurity 30 (CAS 948551-71-1)
- N-(2-(2,2-Di(1H-indol-3-yl)ethyl)phenyl)-4-nitrobenzamide (CAS 88048-47-9)
- Dabigatran Impurity 8 (CAS 1422435-41-3)
- Loratadine impurity 87 (CAS 130642-54-5)
- Argatroban Impurity 128 (CAS CATO-C4X-1007128)
- Deflazacort Impurity 3 (CAS 13649-84-8)
- 2-Amino-1-(4-phenoxyphenyl)ethanol (CAS 153285-74-6)
- N-(4-Fluorophenyl)-N-isopropyl-2-((5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl)oxy)acetamide (CAS 1785763-80-5)
- (6-Chloropyridazin-3-yl)-L-proline (CAS 1008387-77-6)
- 1-(1,5-Dimethyl-1H-pyrazol-4-yl)ethan-1-one (CAS 21686-05-5)
- 4-Ethyl-5-phenylthiophene-2-carboxylic acid (CAS 937599-47-8)
- (1S,2S)-Ethyl 2-(4-(1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate (CAS 1242440-98-7)
- Cyclopeptide-5 (CAS 197172-76-2)
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