Avanafil Impurity 40 CAS 1638497-25-2
| CAS No. | 1638497-25-2 |
| Molecular Formula | C18H21ClN4O4 |
| Molecular Weight | 392.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Avanafil Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Avanafil Impurity 40 (CAS 1638497-25-2), a pharmacopoeial impurity reference standard (molecular formula C18H21ClN4O4, MW 392.84 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Avanafil Impurity 40 (C18H21ClN4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H21ClN4O4 |
| Molecular Weight | 392.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Avanafil Standards
- Avanafil Impurity 125 (CAS CATO-C4X-1118125)
- Avanafil Impurity 27 (CAS 330785-84-7)
- Avanafil Impurity 5 (CAS 372117-54-9)
- Avanafil Impurity 89 (CAS 2250243-36-6)
- Avanafil Impurity 131 (CAS CATO-C4X-1118131)
- Avanafil Impurity 19 (CAS 2250242-12-5)
- Avanafil Impurity 88 (CAS 2250243-52-6)
- Avanafil Impurity 78 (CAS 372117-76-5)
Recommended Standards
- H-Glu-Gly-Arg-chloromethylketone (CAS 65113-67-9)
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- N-(3-Chloro-4-fluorophenyl)-2-((4-ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573707-56-9)
- Benzyl 4-(((4-chloro-2-fluorophenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate (CAS 1330583-65-7)
- Vilanterol Impurity 86 (CAS 2514696-13-8)
- Cefixime Impurity 13 (CAS CATO-C4X-113913)
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- tert-Butyl (S)-3-(2,4-dimethoxybenzyl)piperazine-1-carboxylate (CAS 1260614-23-0)
- 3-(3-(4-Fluorophenyl)-1h-pyrazol-1-yl)propan-1-amine (CAS 1006480-30-3)
- Ethyl (3e)-4-ethoxy-3-methyl-2-oxobut-3-enoate (CAS 1071847-27-2)
- Methyl 5-ethyl-7-(3-hydroxyphenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate (CAS 879935-79-2)
- 6-(2,4-Dimethylphenoxy)nicotinaldehyde (CAS 1216157-59-3)
- N-(3-(6-iodoimidazo[1,2-a]pyridin-2-yl)phenyl)thiophene-2-sulfonamide (CAS 685107-89-5)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
Why CATO?
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