Fluticasone Impurity N1 CAS 16420-13-6

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.16420-13-6
Molecular FormulaC3H6ClNS
Molecular Weight123.60 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Fluticasone Impurity N1 CAS 16420-13-6 chemical structure

Description

As a process- or degradation-related impurity, Fluticasone Impurity N1 (CAS 16420-13-6, C3H6ClNS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to sulfur-containing functionality, chlorine substitution, Fluticasone Impurity N1 is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 123.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC3H6ClNS
Molecular Weight123.60 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)1.0
CAS Registry Year (est.)1961
Halogen ContentCl-containing
Nitrogen Atoms1
Sulfur Atoms1

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