Fluticasone Impurity 52 CAS 32488-17-8
| CAS No. | 32488-17-8 |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Fluticasone Impurity 52 (CAS 32488-17-8) is a certified pharmaceutical impurity reference standard with the molecular formula C9H13NO2 and a molecular weight of 167.21 g/mol.
Based on its molecular formula C9H13NO2, Fluticasone Impurity 52 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 167.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Nitrogen Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Impurity N1 (CAS 16420-13-6)
- Fluticasone Impurity 4 (CAS 105638-31-1)
- Fluticasone Impurity N9 (CAS 3863-16-9)
- Fluticasone Impurity 85 (CAS CATO-C4X-165085)
- Fluticasone Impurity 40 (CAS 25256-97-7)
- Fluticasone Impurity 87 (CAS CATO-C4X-165087)
- Fluticasone Impurity N11 (CAS 192191-46-1)
- Fluticasone Impurity 78 (CAS CATO-C4X-165078)
Recommended Standards
- Carvedilol Impurity 5 (CAS 1836-62-0)
- Gabapentin EP Impurity B (CAS 133481-09-1)
- Oxedrine (CAS 94-07-5)
- Epinephrine /Adrenaline Impurity 131 (CAS CATO-C4X-1849131)
- Fluocinolone Acetonide Impurity 47 (CAS 389119-98-6)
- Leuprorelin EP Impurity D 2*Trifluoroacetic acid (CAS 1926163-25-8 (free base))
- Bendamustine impurity 33 (CAS 109882-25-9)
- 3-Allyl-4-hydroxy-6-methyl-2H-pyran-2-one (CAS 50607-36-8)
- Fmoc-tBu-Gly-OH (CAS 132684-60-7)
- Methyl 1-(difluoromethyl)-1H-pyrazole-4-carboxylate (CAS 2101196-06-7)
- (S)-2-(3-((3,3-dimethylbutyl)sulfonyl)propyl)pyrrolidine (CAS 1670273-46-7)
- 3-(2-Isopropylphenoxy)piperidine hydrochloride (CAS 1220033-52-2)
- [2-(propan-2-yl)-1,3-oxazol-4-yl]methanol (CAS 162740-03-6)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
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