Macitentan Impurity 15 CAS 1642873-04-8
| CAS No. | 1642873-04-8 |
| Molecular Formula | C12H10BrClN2O2 |
| Molecular Weight | 329.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Macitentan Impurity 15 (CAS 1642873-04-8) is a certified pharmaceutical impurity reference standard with the molecular formula C12H10BrClN2O2 and a molecular weight of 329.58 g/mol.
Based on its molecular formula C12H10BrClN2O2, Macitentan Impurity 15 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 329.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Macitentan Impurity 15 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H10BrClN2O2 |
| Molecular Weight | 329.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Macitentan Standards
- Macitentan Impurity 46 (CAS CATO-C4X-117546)
- Macitentan Impurity 14 (CAS 2211059-05-9)
- Macitentan Impurity 48 (CAS CATO-C4X-117548)
- Macitentan Impurity 41 (CAS CATO-C4X-117541)
- Macitentan Impurity 39 (CAS CATO-C4X-117539)
- Macitentan Impurity 50 (CAS 2253990-09-7)
- Macitentan Impurity 45 (CAS CATO-C4X-117545)
- Macitentan Impurity 42 (CAS CATO-C4X-117542)
Recommended Standards
- 36332-93-1 7STP871R4S Methylarachidic acid UNII-7STP871R4S 18-Methyleicosanoic acid Anteisoheneicosanoic acid Eicosanoic acid, 18-methyl- 18-MEA (CAS 36332-93-1)
- 3-Bromo-4-(2-methoxyethoxy)benzene-1-sulfonyl chloride (CAS 1094253-67-4)
- Ethyl 1-(4-bromophenyl)-5-chloro-1H-pyrazole-4-carboxylate (CAS 98475-72-0)
- 5-Bromo-2-(2-methoxyethoxy)benzene-1-sulfonyl chloride (CAS 1247381-44-7)
- Carbetocin Impurity 14 (CAS CATO-C4X-191114)
- Estetrol Impurity 3 (CAS CATO-C4X-32503)
- Cefminox impurity 55 (CAS CATO-C4X-192655)
- Cobimetinib (R)-Isomer (CAS 934660-94-3)
- 5-(Chloromethyl)-2-methanesulfonyl-1-(3-methylbutyl)-1h-imidazole (CAS 1221342-70-6)
- 1-Boc-4-bromo-1,2,3,6-tetrahydropyridine (CAS 159503-91-0)
- 7-CHloro-1h-pyrido[2,3-b][1,4]oxazin-2-ol (CAS 2065250-37-3)
- N1-(3-Fluoro-4-methylphenyl)-N2-((3-methoxytetrahydrothiophen-3-yl)methyl)oxalamide (CAS 1448123-81-6)
- Ethyl 5-amino-4-chloro-1-(pentan-3-yl)-1H-pyrazole-3-carboxylate (CAS 1427012-92-7)
- Semaglutide impurity 81 (CAS CATO-C4X-222681)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com