Macitentan Impurity 48 CAS CATO-C4X-117548
| CAS No. | CATO-C4X-117548 |
| Molecular Formula | C10H5Cl2IN2 |
| Molecular Weight | 350.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 350.97 g/mol gives Macitentan Impurity 48 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Macitentan Impurity 48 (CAS CATO-C4X-117548) is a certified pharmaceutical impurity reference standard with the molecular formula C10H5Cl2IN2 and a molecular weight of 350.97 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/iodine substitution, Macitentan Impurity 48 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 350.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Macitentan Impurity 48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H5Cl2IN2 |
| Molecular Weight | 350.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 2 |
Related Macitentan Standards
- Macitentan Impurity 41 (CAS CATO-C4X-117541)
- Macitentan Impurity 46 (CAS CATO-C4X-117546)
- Macitentan Impurity 39 (CAS CATO-C4X-117539)
- Macitentan Impurity 50 (CAS 2253990-09-7)
- Macitentan Impurity 45 (CAS CATO-C4X-117545)
- Macitentan Impurity 15 (CAS 1642873-04-8)
- Macitentan Impurity 54 (CAS CATO-C4X-117554)
- Macitentan Impurity 17 (CAS 2211054-90-7)
Recommended Standards
- 2-Bromo-3-trifluoromethylphenylboronic acid pinacol ester (CAS 2121513-56-0)
- 5-Bromo-1-ethyl-3-iodo-1H-pyrrolo[2,3-c]pyridine (CAS 1690341-99-1)
- 2-(3-Bromo-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 479411-92-2)
- 6-Dromo-3-iodo-1,4-dimethyl-1H-indazole (CAS 2766312-10-9)
- Tirofiban Impurity 84 (CAS CATO-C4X-125484)
- Carbazochrome Impurity N6 (CAS 25574-55-4)
- Alfacalcidol Impurity 30 (CAS CATO-C4X-139330)
- N-(benzoyloxy)-N-phenylbenzamide (CAS 16817-95-1)
- N-(5-oxo-2,5-dihydrofuran-2-yl)acetamide (CAS 16275-44-8)
- 4-(2-Formylfuran-3-yl)benzoic acid (CAS 1823244-05-8)
- 2-(3-((Tert-butoxycarbonyl)amino)azetidin-1-yl)-2-(2-fluorophenyl)acetic acid (CAS 887594-64-1)
- Methyl (2S,4S)-1-Boc-4-(trifluoromethyl)pyrrolidine-2-carboxylate (CAS 1523541-90-3)
- 1-(3-Bromobenzoyl)piperidine-2-carboxamide (CAS 1008692-77-0)
- Galanin (1-13)-Neuropeptide Y (25-36) amide (CAS 147138-51-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com