Pemetrexed EP Impurity B&C CAS 1644286-34-9
| CAS No. | 1644286-34-9 |
| Molecular Formula | 2*C40H40N10O13 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Pemetrexed EP Impurity B&C is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 868.82 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Pemetrexed EP Impurity B&C (CAS 1644286-34-9) is a certified pharmaceutical impurity reference standard with the molecular formula C40H40N10O13 and a molecular weight of 868.82 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C40H40N10O13 |
| Molecular Weight | 868.82 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 26.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 10 |
Related Pemetrexed Standards
- Pemetrexed Impurity 21 (CAS 1001-19-0)
- Pemetrexed Impurity 11 (CAS 100643-27-4)
- Pemetrexed Impurity 22 (CAS 1075-59-8)
- Pemetrexed Impurity 54 (CAS 1265908-58-4)
- Pemetrexed EP Impurity D Trisodium salt (CAS 1265908-59-5)
- Pemetrexed Impurity (CAS 1265908-60-8)
- Pemetrexed Impurity (CAS 1265908-61-9)
- Pemetrexed Impurity 53 (CAS 1320346-37-9)
Recommended Standards
- Azilsartan Impurity 165 (CAS CATO-C4X-1096165)
- Terbinafine Impurity 44 (CAS CATO-C4X-133844)
- Olaparib impurity 139 (CAS 42086-73-7)
- (5-Aminopyridin-3-yl)(pyrrolidin-1-yl)methanone (CAS 1514619-95-4)
- 3-Amino-5,8-diphenyl-1,2,4-triazocine (CAS 109367-42-2)
- Tert-butyl 5-methylspiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1129411-47-7)
- 1-Methyl-N-(thiazol-5-ylmethyl)-1h-pyrazol-3-amine (CAS 1341282-95-8)
- 5-(Ethylsulfonyl)-4-(2-fluorophenyl)thiazol-2-amine (CAS 1708445-07-1)
- 2-Amino-4-methyl-5-pentylthiophene-3-carboxamide (CAS 68746-23-6)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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