Cabotegravir Impurity 11 CAS 1646862-08-9
| CAS No. | 1646862-08-9 |
| Molecular Formula | C19H17F2N3O5 |
| Molecular Weight | 405.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Cabotegravir Impurity 11 (CAS 1646862-08-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17F2N3O5 and a molecular weight of 405.35 g/mol.
Cabotegravir Impurity 11 (C19H17F2N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Cabotegravir Impurity 11 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H17F2N3O5 |
| Molecular Weight | 405.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Cabotegravir Standards
- Cabotegravir (CAS 1051375-10-0)
- Cabotegravir Impurity 13 (CAS CATO-C4X-287613)
- Cabotegravir Impurity 16 (CAS 2883234-39-5)
- Cabotegravir Impurity 9 (CAS CATO-C4X-28769)
- Cabotegravir Impurity 2 (CAS CATO-C4X-28762)
- Cabotegravir Impurity 24 (CAS CATO-C4X-287624)
- Cabotegravir Impurity 10 (CAS CATO-C4X-287610)
- Cabotegravir Impurity 21 (CAS 2883234-40-8)
Recommended Standards
- Dolutegravir Impurity 31 (CAS CATO-C4X-162031)
- N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide (CAS 293753-05-6)
- K-Ras(G12C) inhibitor 6 (CAS 2060530-16-5)
- 1-Amino-5-hydroxy-4-((2-methoxyphenyl)amino)-8-nitroanthracene-9,10-dione (CAS 71412-38-9)
- Cefradine EP Impurity D (CAS CATO-C4X-12156)
- Mivacurium chloride Impurity 76 (CAS CATO-C4X-137576)
- Varenicline Impurity 62 (CAS CATO-C4X-196262)
- (5E)-5-(4-Fluorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one (CAS 402-93-7)
- 6-(4-Isopropylpiperazin-1-yl)-5-methylnicotinic acid (CAS 1355189-28-4)
- tert-Butyl 3-ethylpiperidine-3-carboxylate hydrochloride (CAS 2126161-65-5)
- n-(3-Bromo-6-chloroimidazo[1,2-b]pyridazin-2-yl)acetamide (CAS 1823781-73-2)
- Trimethylamine oxide hydrochloride (CAS 7651-88-9)
- 1-(2-Methoxyethyl)-2,3-dimethyl-1h-indole-5-carboxylic acid (CAS 1036442-64-4)
- Semaglutide impurity 204 (CAS CATO-C4X-2226204)
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