Dolutegravir Impurity 28 CAS 1646862-09-0
| CAS No. | 1646862-09-0 |
| Molecular Formula | C18H16F2N2O6 |
| Molecular Weight | 394.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dolutegravir Impurity 28 (CAS 1646862-09-0) is a certified pharmaceutical impurity reference standard with the molecular formula C18H16F2N2O6 and a molecular weight of 394.33 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Dolutegravir Impurity 28 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 394.33 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Dolutegravir Impurity 28 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H16F2N2O6 |
| Molecular Weight | 394.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Dolutegravir Standards
- Dolutegravir Impurity 46 (CAS 2244245-34-7)
- Dolutegravir Impurity 50 (CAS CATO-C4X-162050)
- Dolutegravir Impurity 23 (CAS CATO-C4X-162023)
- Dolutegravir Impurity 8 (CAS 1863916-88-4)
- Dolutegravir Impurity 9 (CAS 1863916-87-3)
- Dolutegravir Impurity 5 (CAS 2244161-71-3)
- Dolutegravir Impurity 31 (CAS CATO-C4X-162031)
- Dolutegravir Impurity 48 (CAS CATO-C4X-162048)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com