Iohexol EP Impurity H (4,6-diiodo Isomer) (Mixture of Diastereomers) CAS 1651211-79-8

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.1651211-79-8
Molecular FormulaC20H30IN3O9
Molecular Weight583.37 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Iohexol EP Impurity H (4,6-diiodo Isomer) (Mixture of Diastereomers) CAS 1651211-79-8 chemical structure

Description

The occurrence of Iohexol EP Impurity H (4,6-diiodo Isomer) (Mixture of Diastereomers) is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Iohexol EP Impurity H (4,6-diiodo Isomer) (Mixture of Diastereomers) (CAS 1651211-79-8) is a certified pharmaceutical impurity reference standard with the molecular formula C20H30IN3O9 and a molecular weight of 583.37 g/mol.

The molecular framework of Iohexol EP Impurity H (4,6-diiodo Isomer) (Mixture of Diastereomers) (C20H30IN3O9) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Iohexol EP Impurity H (4,6-diiodo Isomer) (Mixture of Diastereomers) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC20H30IN3O9
Molecular Weight583.37 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor)
Purity97%+
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)7.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1993
Halogen ContentI-containing
Nitrogen Atoms3

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