Rotigotine Impurity N39 CAS 165950-84-5
| CAS No. | 165950-84-5 |
| Molecular Formula | C13H19NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Rotigotine Impurity N39 (CAS 165950-84-5) is a certified pharmaceutical impurity reference standard with the molecular formula C13H19NOHBr and a molecular weight of 286.21 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Rotigotine Impurity N39 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 286.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rotigotine Impurity N39 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H19NO HBr |
| Molecular Weight | 286.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Rotigotine Standards
- Rotigotine Impurity 11 (CAS 101403-24-1)
- Rotigotine impurity 23 (CAS 101470-23-9)
- Rotigotine EP Impurity B Hydrochloride (CAS 101470-23-9（free base）)
- Rotigotine Racemate HCl (CAS 102120-99-0)
- Rotigotine Impurity 40 (CAS 102121-00-6)
- Rotigotine EP Impurity A (CAS 112835-48-0)
- Rotigotine EP Impurity A HCl (CAS 112835-48-0（free base）)
- Rotigotine EP Impurity H (CAS 1148154-91-9)
Recommended Standards
- Acalabrutinib Impurity N1 (CAS 1952316-43-6)
- Tofacitinib Impurity 118 (CAS 1615709-89-1)
- Loxoprofen impurity 74 (CAS CATO-C4X-148874)
- 5-carbamoyl-1H-pyrrole-2-carboxylic acid (CAS 1820641-87-9)
- Methyl 2-cyano(2,2-dimethyltetrahydro-4H-pyran-4-ylidene)acetate (CAS 14389-99-2)
- 2-(4-Methylpyridin-3-yl)-2-(pyrrolidin-1-yl)ethan-1-amine (CAS 1497116-06-9)
- (R)-3-(Pyridin-2-yl)morpholine (CAS 1213223-55-2)
- (E)-2-(4-(tert-butyl)benzyl)-6-(4-methylstyryl)pyridazin-3(2H)-one (CAS 306979-90-8)
- Ponceau SX (CAS 4548-53-2)
- [His]1-Acetylated Semaglutide (CAS CATO-C4X-2226219)
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